2. Protein Tyrosine Kinase/RTK GPCR/G Protein
  3. IGF-1R TSH Receptor
  4. Teprotumumab

Teprotumumab  (Synonyms: 替妥木单抗)

目录号: HY-P99165 纯度: 99.46%
COA

摩尔计算器

Teprotumumab 是一种阻断 IGF-1 受体 (IGF-1R) 的人单克隆抗体。Teprotumumab 与 IGF-1R 的细胞外 α-亚基结构域配体结合。Teprotumumab 抑制纤维细胞中的 TSH 和 IGF-1 作用。Teprotumumab 可降低 TSH 依赖性 IL-6 和 IL-8 的表达和 Akt 的磷酸化。Teprotumumab 可用于甲状腺相关眼病的研究。

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CAS No. : 1036734-93-6

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规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥6000
In-stock
10 mg ￥9600
In-stock
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100 mg   询价  

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Teprotumumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Teprotumumab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

替妥木单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78142) on AHC2 biosensor, can bind Teprotumumab with an affinity constant of 4.315E-10 M as determined in BLI assay.
纯度 & 产品资料
参考文献

Teprotumumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teprotumumab1036734-93-6替妥木单抗IGF-1RTSH ReceptorInsulin-like growth factor-1 receptorThyrotropin receptorThyroid-stimulating hormone Receptorthyroid-associated ophthalmopathyTAOfibrocytesInhibitorinhibitorinhibit

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