2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TET-13

TET-13 是一种 GABAA 受体的正向变构调节剂，EC50 为 5.65 μM，低于 Etomidate (EC50: 9.29 μM)。TET-13 对小鼠和大鼠均表现出强效的麻醉作用 (ED50 分别为 0.48 mg/kg 和 0.69 mg/kg)。

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TET-13 Chemical Structure

TET-13 Chemical Structure

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TET-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TET-13 is a positive allosteric modulator of GABAA receptor with an EC50 of 5.65 μM, lower than that of Etomidate (EC50: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED50: 0.48 mg/kg and 0.69 mg/kg, respectively)[1].

体外研究
(In Vitro)

TET-13 (1 mg/mL, 0-30 min) 在 SD 大鼠血浆中代谢迅速，半衰期 T1/2 为 0.48 min[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TET-13 相关抗体:
体内研究
(In Vivo)

TET-13 (小鼠为 1.2 mg/kg, 大鼠为 1.725 mg/kg，静脉注射) 对小鼠和大鼠均表现出强效的麻醉作用 (ED50 分别为 0.48 mg/kg 和 0.69 mg/kg)，比依托咪酯更快恢复[1]。
TET-13 (1.38 mg/kg, 静脉注射) 对大鼠血清皮质酮几乎无抑制作用，浓度为 970.12 nM[1]。
TET 13 (22 mg/kg/h) 持续输注诱导大鼠0.5、1 和 2 小时后的恢复时间和行走时间均短于依托咪酯[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice, rats[1]
Dosage: 2.5 ×ED50 (ED50: 0.48 mg/kg (mice) and 0.69 mg/kg, (rats))
Administration: Intravenous injection (i.v.)
Result: Exhibited faster recovery compared to Etomidate (the times to walk: 27.88 s and 107.80 s, respectively) in mice.
Showed the incidence of myoclonus is 100% in mice.
Showed faster onset time (3.04 s) than etomidate in rats.
Showed the incidence of myoclonus was 0 % in rats.
分子量

304.36

Formula

C15H16N2O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TET-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TET-13TET13TET 13GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorAnesthesiaHypnotic effectLORRMyoclonusHalf-life.Inhibitorinhibitorinhibit

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目录号：
HY-169432
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