2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Tetrahydrofolic acid trihydrochloride

Tetrahydrofolic acid trihydrochloride  (Synonyms: L-5,6,7,8-Tetrahydrofolic acid trihydrochloride; L-Tetrahydrofolic acid trihydrochloride)

目录号: HY-14520B
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摩尔计算器

Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride 是一种具有生物活性的维生素 B9 叶酸衍生物，是氨基酸，核酸和脂质的一个碳原子的供体。Tetrahydrofolic acid trihydrochloride 用作游离甲醛的受体，产生 5,10-亚甲基四氢叶酸-四氢叶酸。

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Tetrahydrofolic acid trihydrochloride Chemical Structure

Tetrahydrofolic acid trihydrochloride Chemical Structure

CAS No. : 150731-85-4

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Tetrahydrofolic acid trihydrochloride 的其他形式现货产品:

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Tetrahydrofolic acid trihydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Tetrahydrofolic acid (0 -200 μM；3 天；Adh5-/- DT40 细胞) trihydrochloride 暴露对 Adh5 和范可尼贫血 (FA) 缺陷细胞具有细胞毒性，产生广泛的 DNA 损伤和染色体累积中断[1]。
Tetrahydrofolic acid (0-100 μM；16 小时；Adh5-/- DT40 细胞) trihydrochloride 处理强烈促进 FANCD2 和 ser139-H2AX 聚焦在 Adh5-/- 细胞中以剂量依赖性方式形成[1]。
由于不受控制的活动，Tetrahydrofolic acid trihydrochloride 暴露会激活 DNA 损伤反应 (DDR) 胸苷酸合成酶的作用，导致必需核苷酸耗尽，并通过同源重组机制促进修复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrahydrofolic acid trihydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Adh5-/- DT40 cells
Concentration: 0-200 µM
Incubation Time: 3 days
Result: Viability of Adh5-/-DT40 cells rapidly dropped.

Western Blot Analysis[1]

Cell Line: Adh5-/- DT40 cells
Concentration: 0-200 µM
Incubation Time: 16 hours
Result: Strongly promoted FANCD2 and ser139-H2AX focus formation in Adh5-/- cells in a dose-dependent manner.
体内研究
(In Vivo)

Tetrahydrofolic acid (62.5 mg/kg；腹膜内注射；每天；Adh5-/- 小鼠) trihydrochloride 处理扰乱造血细胞的造血功能，增加 ser139-H2AX 磷酸化，并降低祖细胞 (HSPC) 的存活率表明过量的 Tetrahydrofolic acid trihydrochloride 可能对骨髓细胞具有致突变性和遗传毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adh5-/- mice[1]
Dosage: 62.5 mg/kg
Administration: Intraperitoneal injection; daily
Result: Perturbed hematopoiesis, increased ser139-H2AX phosphorylation, and decreased the survival of progenitor cells (HSPCs).
分子量

554.81

Formula

C19H26Cl3N7O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tetrahydrofolic acid trihydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydrofolic acid trihydrochloride150731-85-4L-5,6,7,8-Tetrahydrofolic acid trihydrochlorideL-Tetrahydrofolic acid trihydrochlorideEndogenous MetaboliteFolatederivativewater-solublevitamin5,10-methylenetetrahydrofolatehematopoiesisFANCD2one-carbonDNAaminonucleiclipidsInhibitorinhibitorinhibit

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