2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TGFβ-IN-1

TGFβ-IN-1通过抑制转化生长因子β信号通路而成为抗肿瘤生长和转移剂。

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TGFβ-IN-1 Chemical Structure

TGFβ-IN-1 Chemical Structure

CAS No. : 883560-84-7

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TGFβ-IN-1 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
< 0.5 μM
Compound: 8d
Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
[PMID: 24417479]
A549 IC50
0.1 μM
Compound: 8d
Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay
Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay
[PMID: 24417479]
A549 IC50
7.9 μM
Compound: 8d
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
[PMID: 24417479]
NCI-H1299 IC50
< 0.5 μM
Compound: 8d
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
[PMID: 24417479]
NCI-H1299 IC50
0.1 μM
Compound: 8d
Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay
Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay
[PMID: 24417479]
NCI-H1299 IC50
8.07 μM
Compound: 8d
Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay
Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay
[PMID: 24417479]
PC-9 IC50
5.87 μM
Compound: 8d
Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay
Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay
[PMID: 24417479]
分子量

290.36

Formula

C19H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGFβ-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβ-IN-1883560-84-7TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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