2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TGFβ1-IN-2

TGFβ1-IN-2 是一种二芳基酰基腙衍生物，可有效抑制成纤维细胞的活化和增殖。TGFβ1-IN-2 可用于特发性肺纤维化 (IPF) 研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TGFβ1-IN-2 Chemical Structure

TGFβ1-IN-2 Chemical Structure

CAS No. : 2883813-66-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TGFβ1-IN-2 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGFβ1-IN-2 is a diarylacylhydrazones derivative that effectively suppresses the activation and proliferation of fibroblasts. TGFβ1-IN-2 can be used for idiopathic pulmonary fibrosis (IPF) research[1].

体外研究
(In Vitro)

TGFβ1-IN-2 (compound 52) shows inhibitory effect against NIH-3T3 cells with an IC50 of 1.36 μM[1].
TGFβ1-IN-2 (compound 52; 6 μM; for 24 h) inhibits TGF-β1-induced abnormal activation of NIH-3T3 and A549 cells, as well as migration and epithelial-mesenchymal transition (EMT) of A549 cells[1].
TGFβ1-IN-2 (compound 52) could bind to STAT3, and able to interact with Ile659, and the hydrophilic group piperidine formed intermolecular forces with Ser636, Arg609, and Pro639[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TGFβ1-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: NIH-3T3 or A549 cells
Concentration: 6 μM
Incubation Time: 24 h
Result: Were able to inhibit TGF-β1-induced activation of fibroblasts in vitro.
体内研究
(In Vivo)

TGFβ1-IN-2 (compound 52; 30-60 mg/kg; p.o; once daily; for 22 days) improves mouse lung function and slowsthe progression of IPF. TGFβ1-IN-2 could reverse the pulmonary fibrosis in treatment model[1].
Pharmacokinetic parameters of TGFβ1-IN-2 (compound 52) in rats[1].

PK parameter TGFβ1-IN-2 (Compound 52)
i.v. p.o.
Dose (mg/kg) 2 20
Cmax (ng/mL) 470.58±60.67 351.01±85.44
Tmax (h) 0.08 2.17
AUC0-∞ (h·ng/mL) 370.81±76.46 1503.71±319.62
CL (mL/h/kg) 5565.86±1257.13 -
T1/2 (h) 0.93±0.43 1.23±0.15
F (%) - 42.08±8.93

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (6-10 weeks) injected with Bleomycin for establishing pulmonary fibrosis model[1].
Dosage: 30 mg/kg, 60 mg/kg
Administration: Orally administration; once daily; for 22 days
Result: Could reverse the pulmonary fibrosis in treatment model.
分子量

458.57

Formula

C23H30N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGFβ1-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβ1-IN-22883813-66-7TGF-β ReceptorTransforming growth factor beta receptorsTGF-β1diarylacylhydrazones derivativeidiopathic pulmonary fibrosisepithelial-mesenchymal transitionSTAT3Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TGFβ1-IN-2
目录号：
HY-151954
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z