2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-4-C3-NH2 hydrochloride

Thalidomide-4-C3-NH2 hydrochloride 

目录号: HY-139545
产品使用指南

摩尔计算器

Thalidomide-4-C3-NH2 hydrochloride 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-4-C3-NH2 hydrochloride 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子

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Thalidomide-4-C3-NH2 hydrochloride Chemical Structure

Thalidomide-4-C3-NH2 hydrochloride Chemical Structure

CAS No. : 2357110-84-8

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Thalidomide-4-C3-NH2 hydrochloride 相关抗体

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查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-4-C3-NH2 hydrochloride 相关抗体:
分子量

351.78

Formula

C16H18ClN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thalidomide-4-C3-NH2 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-4-C3-NH22357110-84-8E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisThalidomideCRBNPROTACInhibitorinhibitorinhibit

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