2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-4-O-CH2-COO(t-Bu)

Thalidomide-4-O-CH2-COO(t-Bu) 是t-Bu 修饰的 Thalidomide (HY-14658)，是合成 Thalidomide-4-OH (HY-123096) 的最后一步中间体。Thalidomide-4-O-CH2-COO(t-Bu) 可作为 Cereblon?配体，募集 CRBN?蛋白。Thalidomide-4-O-CH2-COO(t-Bu) 末端的 t-Bu 保护基团，可在酸性条件下脱除，进而参与 PROTAC 分子的合成。Thalidomide-4-O-CH2-COO(t-Bu) 是基于 CRBN 设计的 PROTAC 分子合成过程中的关键中间体。

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Thalidomide-4-O-CH2-COO(t-Bu) Chemical Structure

Thalidomide-4-O-CH2-COO(t-Bu) Chemical Structure

CAS No. : 1950635-36-5

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规格 价格 是否有货 数量
10 mg ￥200
1 - 2 周
25 mg ￥400
1 - 2 周
50 mg ￥600
1 - 2 周
100 mg ￥960
1 - 2 周
200 mg   询价  
500 mg   询价  

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Thalidomide-4-O-CH2-COO(t-Bu) 相关抗体

Top Publications Citing Use of Products

查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.

IC50 & Target

Cereblon

 

分子量

388.37

Formula

C19H20N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thalidomide-4-O-CH2-COO(t-Bu) 相关分类

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Keywords:

Thalidomide-4-O-CH2-COO(t-Bu)1950635-36-5E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisLigands for E3 LigaseInhibitorinhibitorinhibit

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