2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-amido-PEG4-C2-NH2

Thalidomide-O-amido-PEG4-C2-NH2 

目录号: HY-122710
产品使用指南

摩尔计算器

Thalidomide-O-amido-PEG4-C2-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride。

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Thalidomide-O-amido-PEG4-C2-NH2 Chemical Structure

Thalidomide-O-amido-PEG4-C2-NH2 Chemical Structure

CAS No. : 1957236-22-4

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Thalidomide-O-amido-PEG4-C2-NH2 的其他形式现货产品:

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Other Forms of Thalidomide-O-amido-PEG4-C2-NH2:

Thalidomide-O-amido-PEG4-C2-NH2 相关抗体

Top Publications Citing Use of Products

查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-O-amido-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-amido-PEG4-C2-NH2 相关抗体:
分子量

550.56

Formula

C25H34N4O10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thalidomide-O-amido-PEG4-C2-NH2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-PEG4-C2-NH21957236-22-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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