1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Thymine-d4-1

Thymine-d4-1 是 Thymine 的氘代物。 Thymine 是 DNA 的四个碱基之一,在动物癌症模型中,可以作为5-氟尿嘧啶 (5-FU) 的靶标,其 Km 值为 2.3 μM。

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Thymine-d<sub>4</sub>-1 Chemical Structure

Thymine-d4-1 Chemical Structure

CAS No. : 156054-85-2

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Other Forms of Thymine-d4-1:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thymine-d4-1 is the deuterium labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

130.14

Formula

C5H2D4N2O2

CAS 号
非标记 CAS

65-71-4

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Thymine-d4-1
目录号:
HY-W010450S4
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