Tiagabine-d₅ hydrochloride  (Synonyms: 盐酸噻加宾-d₅; NO050328-d₅ hydrochloride; NO328-d₅ hydrochloride; TGB-d₅ hydrochloride)

Tiagabine-d₅ (hydrochloride) is deuterium labeled Tiagabine (hydrochloride). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively^[1][2].

417.04

C₂₀H₂₁D₅ClNO₂S₂

1253297-72-1

145821-59-6

盐酸噻加宾-d₅；盐酸替加宾-d₅；盐酸塞加宾-d₅；盐酸硫加宾-d₅

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.  [Content Brief]

  [3]. Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40.  [Content Brief]

  [4]. Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70.  [Content Brief]