2. Protein Tyrosine Kinase/RTK
  3. Tie
  4. Tie2 kinase inhibitor 3

Tie2 kinase inhibitor 3 (compound 63) 是一种有良好口服活性的 Tie-2 激酶强效抑制剂 (IC50=30 nM)。Tie2 kinase inhibitor 3 通过与 Tie-2 激酶的 ATP 结合位点竞争，抑制 Tie-2 的磷酸化和信号传导。这种抑制作用会影响血管的稳定性和成熟度，从而对肿瘤血管生成产生影响。Tie2 kinase inhibitor 3 可用于限制肿瘤生长和调节血管生成的研究。

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Tie2 kinase inhibitor 3 Chemical Structure

Tie2 kinase inhibitor 3 Chemical Structure

CAS No. : 870225-11-9

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Tie2 kinase inhibitor 3 相关抗体

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  • 生物活性

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生物活性

Tie2 kinase inhibitor 3 (compound 63) is a potent Tie-2 kinase inhibitor with good oral activity (IC50=30 nM). Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of Tie-2 by competing with the ATP binding site of Tie-2 kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis[1].

分子量

598.59

Formula

C29H30F4N8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tie2 kinase inhibitor 3 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tie2 kinase inhibitor 3870225-11-9TieAngiopoietin receptorInhibitororal activityphosphorylationtumor angiogenesisTie-2 Kinaseinhibitorinhibit

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