2. Neuronal Signaling
  3. Tau Protein
  4. Tilavonemab

Tilavonemab  (Synonyms: 替拉奈单抗; ABBV-8E12; C2N-8E12)

目录号: HY-P99163 纯度: 96.22%
COA 技术支持

Tilavonemab (ABBV-8E12) 是一种人源化抗 tau 抗体，通过结合 tau 蛋白的 N 端 25-30 氨基酸残基来靶向病理 tau 蛋白聚集的细胞外形式。Tilavonemab 阻断人和小鼠神经元摄取 tau 聚集体的能力，在表达突变的人类 tau 的转基因小鼠中，减少了脑容量的损失，减缓了 tau 病理的进展，并提高了认知能力。Tilavonemab 可用于阿尔兹海默症的研究。

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CAS No. : 2096513-89-0

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规格 价格 是否有货 数量
1 mg ￥1200
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5 mg ￥3600
In-stock
10 mg ￥6100
In-stock
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Tilavonemab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tilavonemab (ABBV-8E12) is a humanized anti-tau antibody that targets the extracellular form of pathological tau protein aggregates by binding to the N-terminal 25-30 amino acid residues of tau protein. Tilavonemab blocks the ability of human and mouse neurons to take up tau aggregates, reduces the loss of brain volume, slows the progression of tau pathology, and improves cognitive abilities in transgenic mice expressing mutant human tau. Tilavonemab is used in Alzheimer's disease research[1][2][3].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Chimeric
IC50 & Target

tau[1].
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

替拉奈单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human Tau Protein (His Tag) can bind Tilavonemab. The EC50 for this effect is 2.182 ng/mL.
纯度 & 产品资料
参考文献

Tilavonemab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilavonemab2096513-89-0ABBV-8E12 C2N-8E12替拉奈单抗Tau Proteinalzheimer’s diseaseADInhibitorinhibitorinhibit

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