2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Tisotumab vedotin

Tisotumab vedotin 是一种靶向组织因子 (tissue factor, TF) 的抗体-药物偶联物 (ADC)，由组织因子的全人源单克隆抗体 (TF-011) 与微管破坏剂 Monomethyl Auristatin E (MMAE) (HY-15162) 共价连接而成。Tisotumab vedotin 具有免疫调节活性和抗肿瘤活性，可用于晚期或转移性实体瘤如宫颈癌的研究。

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Tisotumab vedotin Chemical Structure

Tisotumab vedotin Chemical Structure

CAS No. : 1418731-10-8

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Tisotumab vedotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tisotumab vedotin is an antibody drug conjugate (ADC) targeting tissue factor (TF), formed by covalently linking a fully human monoclonal antibody (TF-011) against TF with the microtubule disruptor Monomethyll Auristatin E (MMAE) (HY-15162). Tisotumab vedotin has immunomodulatory and anti-tumor activities, and can be used in the study of advanced or metastatic solid tumors such as cervical cancer[1][2][3].
IC50 & Target

tissue factor[1].
体外研究
(In Vitro)

Tisotumab vedotin 在表达 TF 的肿瘤细胞中引起免疫原性细胞死亡，导致内质网应激标志物以及 ATP 和高迁移率组蛋白 B1 (HMGB1) 的释放[1]。
Tisotumab vedotin 通过 MMAE 介导的细胞毒性， Fc 介导的抗体依赖性细胞吞噬作用 (ADCP) 和 Fab 介导的蛋白酶激活受体 2 (PAR-2) 信号转导抑制来诱导抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tisotumab vedotin 相关抗体:
体内研究
(In Vivo)

Tisotumab vedotin 可以导致免疫原性肿瘤细胞死亡并促进 F4/80+ 和 CD11c+ 先天免疫细胞激活后被招募到异种移植肿瘤中[1]。
Tisotumab vedotin (2 mg/kg; 每天 1 次; 25 天) 在胰腺癌小鼠模型中具有抗肿瘤活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HPAF-II, SCID mice[4].
Dosage: 2 mg/kg
Administration: Once daily; 25 days
Result: Decreased the tumor volume over the 3-week window.
Clinical Trial
分子量

152000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 99.69%

COA (266 KB) Others (269 KB) SEC-HPLC (266 KB)

产品使用指南 (1538 KB)
参考文献

Tisotumab vedotin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tisotumab vedotin1418731-10-8Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesADCMonomethyl Auristatin Eimmune regulationcervical carcinomaInhibitorinhibitorinhibit

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产品名称：
Tisotumab vedotin
目录号：
HY-152963
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