2. Cell Cycle/DNA Damage
  3. Antifolate
  4. TNP-351

TNP-351 是一种抗叶酸剂。TNP-351 是一种二氢叶酸还原酶 (DHFR) 抑制剂，在体内外对白血病和实体瘤细胞均具有有效的抗肿瘤活性。

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TNP-351 Chemical Structure

TNP-351 Chemical Structure

CAS No. : 125991-51-7

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TNP-351 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

IC50 & Target

Antifolate, DHFR[1]
体外研究
(In Vitro)

TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1].
The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNP-351 相关抗体:

Cell Viability Assay[1]

Cell Line: L1210 and CCRF-CEM cells
Concentration: 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
Incubation Time: 48 hours for L1210 cells; 72 hours for CCRF-CEM cells
Result: The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
分子量

440.45

Formula

C21H24N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNP-351 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNP-351125991-51-7TNP351TNP 351AntifolateleukemiaantifolatedihydrofolatereductaseDHFRsolidtumorInhibitorinhibitorinhibit

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产品名称：
TNP-351
目录号：
HY-19095
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