2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase II inhibitor 11

Topoisomerase II inhibitor 11 

目录号: HY-147861
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摩尔计算器

Topoisomerase II inhibitor 11 (compound 3d) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂，其 IC50 为 2.89 μM。Topoisomerase II inhibitor 11 对肾癌 A498 细胞有 92.46% 的抑制作用，其 IC50 值为 3.5 μM。Topoisomerase II inhibitor 11 在 G2/M 期引起细胞周期阻滞，导致细胞增殖抑制和促凋亡活性。

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Topoisomerase II inhibitor 11 Chemical Structure

Topoisomerase II inhibitor 11 Chemical Structure

CAS No. : 2476559-00-7

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Topoisomerase II inhibitor 11 相关抗体

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生物活性

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].

IC50 & Target

Topoisomerase II

2.89 μM (IC50)

分子量

588.34

Formula

C27H21BrCl2N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase II inhibitor 11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 112476559-00-7Topoisomerase II inhibitor11Topoisomerase II inhibitor-11TopoisomeraseApoptosisrenal cancerA498Triazolopyrimidinestopoisomerase IIflow cytometryapoptosisInhibitorinhibitorinhibit

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