2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase IIα-IN-1

Topoisomerase IIα-IN-1 (compound 2) 是一种有效的 DNA 结合配体 (DNA-binding ligands) 和拓扑异构酶 TopoIIα 抑制剂。Topoisomerase IIα-IN-1 对人类癌症细胞株具有较高的抗增殖活性。

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Topoisomerase IIα-IN-1 Chemical Structure

Topoisomerase IIα-IN-1 Chemical Structure

CAS No. : 2407521-87-1

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Topoisomerase IIα-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].

IC50 & Target

topoisomerase II alpha

 

topoisomerase II beta

 

体外研究
(In Vitro)

Topoisomerase IIα-IN-1 (compound 2) shows antiproliferative activity in cancer cell lines (CCRF-CEM, CCRF-SB, MT-4, HT-29, MCF-7, HeLa, ACHN, SKMEL-28, and G-361), with IC50 values of 0.02, 0.02, 0.01, 0.003, 0.007, 0.005, 0.008, 0.002, and 0.001 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase IIα-IN-1 相关抗体:
分子量

420.42

Formula

C22H20N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase IIα-IN-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase IIα-IN-12407521-87-1TopoisomeraseMCF-7 cellsbreast cancerpyridophenoxazinonesantiproliferative activityDNA damageanticancer activityleukemiaInhibitorinhibitorinhibit

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