2. Inhibitory Antibodies
  3. Topsalysin

Topsalysin  (Synonyms: PRX-302)

目录号: HY-P99554

摩尔计算器

Topsalysin 是一种 PSA 激活的原蛋白，也是一种与人前列腺特异性抗原融合的孔隙形成蛋白 (合成原气溶素)。Topsalysin 对小鼠模型的肿瘤生长有抑制作用。

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CAS No. : 917121-25-6

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Topsalysin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle[1].

种属

Aeromonas hydrophila
体外研究
(In Vitro)

Topsalysin (19 pM-10 nM; 48 小时) 对 LNCaP, PC3, DU145 和 TSU 细胞显示前列腺特异性抗原 (PSA) 依赖性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topsalysin 相关抗体:
体内研究
(In Vivo)

Topsalysin (肿瘤内注射; 1-10μg /鼠标; 单次剂量) 抑制小鼠的肿瘤生长[1]。
Topsalysin (0.35、4.1、25.8 μg/kg, 25 μL; 腹腔注射; 单剂量) 可杀死食蟹猴前列腺注射部位高达 50% 的细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (6-week-old) subcutaneously bearing tumors[1]
Dosage: 0, 1, 5, and 10 μg
Administration: Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
Result: Showed prostate-specific antigen (PSA)-dependent toxicity in mice.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • proaerolysin (engineered with a PSA cutting site)-hexahistidine
纯度 & 产品资料
参考文献

Topsalysin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topsalysin917121-25-6PRX-302PRX302PRX 302OthersInhibitorinhibitorinhibit

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