2. Epigenetics
  3. Epigenetic Reader Domain
  4. TP-238

TP-238 是一种有效的选择性 CECR2/BPTF 双探针，IC50 值分别为 30 nM 和 350 nM。TP-238 还抑制 BRD9，pIC50 为 5.9，对其他 338 激酶的活性较低。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 TP-238 hydrochloride 通常具有更好的水溶性和稳定性。

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TP-238 Chemical Structure

TP-238 Chemical Structure

CAS No. : 2415263-04-4

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TP-238 的其他形式现货产品:

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Other Forms of TP-238:

TP-238 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].

IC50 & Target[1][2]

CECR2

30 nM (IC50)

CECR2

10 nM (Kd)

CECR2

7.5 (pIC50)

BPTF

350 nM (IC50)

BPTF

120 nM (Kd)

BPTF

6.5 (pIC50)

BRD9

5.9 (pIC50)

体外研究
(In Vitro)

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TP-238 相关抗体:
分子量

458.58

Formula

C22H30N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TP-238 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-2382415263-04-4TP238TP 238Epigenetic Reader DomainCECR2BPTFBRD9probeoff-targetInhibitorinhibitorinhibit

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目录号：
HY-114205
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