2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. TQ05310

TQ05310 是一个口服有效的 IDH2 突变型抑制剂，同时靶向 IDH2‐R140Q (IC50=136.9 nM) 和 IDH2‐R172K (IC50=37.9 nM) 突变体。TQ05310 通过抑制突变体 IDH2 的酶活性，来抑制 2‐羟戊二酸 (2‐HG) 的产生，并诱导表达 IDH2‐R140Q 和 IDH2‐R172K 的细胞分化。TQ05310 可用于急性髓系白血病的研究。

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TQ05310 Chemical Structure

TQ05310 Chemical Structure

CAS No. : 2071196-10-4

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TQ05310 相关抗体

Top Publications Citing Use of Products

查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

查看所有亚型
IDH1 IDH2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia[1].

IC50 & Target[1]

IDH2-R140Q

136.9 nM (IC50)

IDH2‐R172K

37.9 nM (IC50)

分子量

473.37

Formula

C19H17F6N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TQ05310 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TQ053102071196-10-4TQ 05310TQ-05310Isocitrate Dehydrogenase (IDH)MutantInhibitorHydroxyglutarateCell differentiationAcute myeloid leukemiainhibitorinhibit

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