2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. Trivalent hydroxyarsinothricn

Trivalent hydroxyarsinothricn  (Synonyms: R-AST-OH)

目录号: HY-158378
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摩尔计算器

Trivalent hydroxyarsinothricn (R-AST-OH) 是一种共价且不可逆的肾型谷氨酰胺酶 (KGA)抑制剂。Trivalent hydroxyarsinothricn 与谷氨酰胺结合位点结合，并与活性位点半胱氨酸残基形成共价键。Trivalent hydroxyarsinothricn 选择性杀死三阴性乳腺癌 (TNBC) 细胞，且对照细胞系无细胞毒性。KGA 是控制谷氨酰胺代谢的酶，与肿瘤恶性程度相关。

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Trivalent hydroxyarsinothricn Chemical Structure

Trivalent hydroxyarsinothricn Chemical Structure

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Trivalent hydroxyarsinothricn 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy[1].

分子量

211.05

Formula

C4H10AsNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trivalent hydroxyarsinothricn 相关分类

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trivalent hydroxyarsinothricnR-AST-OHGlutaminasebreast cancerTNBCMDA-MB-231KGAInhibitorinhibitorinhibit

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