2. Neuronal Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. Trk Receptor Apoptosis
  4. TRK-IN-23

TRK-IN-23 (compound 24b) 是一种有效的口服活性 TRK 抑制剂，对 TRKA、TRKC、TRKAG595R、TRKAF589L 和 TRKAG667C 的 IC50 值分别为 0.5 nM、9 nM、14 nM、4.4 nM 和 4.8 nM。TRK-IN-23 诱导 Ba/F3-TRKAG595R 和 Ba/F3-TRKAG667C 细胞凋亡 (apoptosis)。

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TRK-IN-23 Chemical Structure

TRK-IN-23 Chemical Structure

CAS No. : 2924344-29-4

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规格 价格 是否有货 数量
5 mg ￥1600
1 - 2 周
10 mg   询价  
50 mg   询价  

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TRK-IN-23 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].

IC50 & Target[1]

TrkA

0.5 nM (IC50)

TrkC

9 nM (IC50)

TRKAG595R

14 nM (IC50)

TRKAF589L

4.4 nM (IC50)

TRKAG667C

4.8 nM (IC50)

分子量

364.37

Formula

C20H17FN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRK-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-232924344-29-4Trk ReceptorApoptosisTropomyosin related kinase receptor TRKATRKCTRKAG595RTRKAF589LTRKAG667Corally activeapoptosisInhibitorinhibitorinhibit

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产品名称：
TRK-IN-23
目录号：
HY-149965
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