2. Metabolic Enzyme/Protease Apoptosis
  3. TrxR Apoptosis
  4. TrxR1-IN-B19

TrxR1-IN-B19 (GO-Y015) (Compound B19) 是一种姜黄素 (Curcumin (HY-N0005)) 衍生物和共价的 TrxR1 抑制剂。TrxR1-IN-B19 抑制 TrxR1 酶活性以升高氧化应激，然后诱导活性氧介导的内质网应激和线粒体功能障碍，最终导致细胞周期停滞和细胞凋亡(apoptosis)。

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TrxR1-IN-B19 Chemical Structure

TrxR1-IN-B19 Chemical Structure

CAS No. : 170950-29-5

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TrxR1-IN-B19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BGC-823 IC50
24.4 μM
Compound: B4
Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
[PMID: 19243951]
HCT-116 GI50
1.3 μM
Compound: GO-Y015
Growth inhibition of human HCT116 cells after 48 hrs by MTS assay
Growth inhibition of human HCT116 cells after 48 hrs by MTS assay
[PMID: 20060305]
HL-60 IC50
24.3 μM
Compound: B4
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 19243951]
KB IC50
4.5 μM
Compound: B4
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 19243951]
LS174T IC50
48 μM
Compound: B4
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
[PMID: 19243951]
NCI-H460 IC50
6.74 μM
Compound: 19
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 21504179]
分子量

354.40

Formula

C21H22O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TrxR1-IN-B19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR1-IN-B19170950-29-5GO-Y015TrxRApoptosisThioredoxin Reductasegastric cancerROSSGC-7901BGC-823 and KATO IIISGC-7901 xenograftInhibitorinhibitorinhibit

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