2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Tubulin inhibitor 14

Tubulin inhibitor 14 是一种有效的醌氧化还原酶 2 (NQO2) 抑制剂，其 IC50 为 1.0 μM。Tubulin inhibitor 14 也可抑制微管蛋白聚合和内皮细胞毛细血管样管的形成。Tubulin inhibitor 14 是一种微管稳定剂，具有潜在的肿瘤选择性、抗血管生成和血管破坏特征。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tubulin inhibitor 14 Chemical Structure

Tubulin inhibitor 14 Chemical Structure

CAS No. : 2767446-34-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Tubulin inhibitor 14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features[1].

IC50 & Target

IC50: 1.0 μM (NQO2)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.27 μM
Compound: 4
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
A549 IC50
0.44 μM
Compound: 4
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
HCT-116 IC50
0.13 μM
Compound: 4
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
HCT-116 IC50
0.13 μM
Compound: 4
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
HepG2 IC50
0.86 μM
Compound: 4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
HepG2 IC50
1.44 μM
Compound: 4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
MCF7 IC50
0.41 μM
Compound: 4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
MCF7 IC50
0.5 μM
Compound: 4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
MDA-MB-231 IC50
0.07 μM
Compound: 4
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
MDA-MB-231 IC50
0.09 μM
Compound: 4
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
SNU-423 IC50
0.25 μM
Compound: 4
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
[PMID: 35290041]
SNU-423 IC50
0.36 μM
Compound: 4
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
[PMID: 35290041]
体外研究
(In Vitro)

Tubulin inhibitor 14 (compound 4) (0-20 μM, 96 h) inhibits cancer cells proliferation [1].
Tubulin inhibitor 14 (1-5 μM, 24 or 48 h) causes G2/M cell cycle arrest[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) induces SNU423 cell apoptosis[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) disrupts the cytoskeleton network in endothelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 14 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HepG2, SNU423, A549, HCT116
Concentration: 0 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, and 20 μM
Incubation Time: 96 h
Result: Inhibited cell proliferation with IC50 values of 0.41 μM (MCF-7) , 0.07 μM (MDA-MB-231), 1.44 μM (HepG2), 0.25 μM (SNU423), 0.27 μM (A549), and 0.13 μM (HCT116).

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 1, 2, 5 μM
Incubation Time: 24 h, 48 h
Result: Caused G2/M cell cycle arrest.

Apoptosis Analysis[1]

Cell Line: SNU423 cells
Concentration: 0.5, 1 μM
Incubation Time: 24 h
Result: Induced SNU423 cell apoptosis.

Immunofluorescence[1]

Cell Line: HUVECs
Concentration: 0.5, 1 μM
Incubation Time: 24 h
Result: Disrupted the cytoskeleton network in endothelial cells.
分子量

257.23

Formula

C15H9F2NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 142767446-34-2Tubulin inhibitor14Tubulin inhibitor-14ApoptosisMicrotubule/TubulinHepG2SNU423 cellsLow cytotoxicityEndothelial cellTumor-selectivityAntiangiogenicVascular disruptingInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Tubulin inhibitor 14
目录号：
HY-145820
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z