2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 47

Tubulin inhibitor 47 (compound C11) 是一种有效的微管蛋白 (tubulin) 抑制剂。Tubulin inhibitor 47 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 M 期。Tubulin inhibitor 47 具有抗肿瘤活性。

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Tubulin inhibitor 47 Chemical Structure

Tubulin inhibitor 47 Chemical Structure

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Tubulin inhibitor 47 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity[1].

体外研究
(In Vitro)

Tubulin inhibitor 47 (compound C11) 靶向微管蛋白的秋水仙碱位点以抑制其聚合[1]。
Tubulin inhibitor 47 (0, 2, 4, 6, 8, 10 nM) 诱导细胞周期停滞在 M 期[1]。
Tubulin inhibitor 47 (0, 5, 10, 20 nM) 以剂量依赖性方式增加 KYSE30 细胞中 p-Histone H3 的表达[1]。
Tubulin inhibitor 47 (0, 5, 10, 20 nM; 48 h) 以剂量依赖性方式诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 47 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MGC-803, KYSE-30, HCT-116 cells
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed antiproliferative activities with IC50s of 0.014, 0.013, 0.026 µM for MGC-803, KYSE-30, HCT-116 cells, respectively.

Apoptosis Analysis[1]

Cell Line: KYSE30, KYSE70 cells
Concentration: 5, 10, 20 nM
Incubation Time: 48 h
Result: Induced apoptosis and decreased the expression of cleaved-PARP, cleaved-caspase 9/7/3 protein.

Cell Cycle Analysis[1]

Cell Line: KYSE30, KYSE70 cells
Concentration: 5, 10, 20 nM
Incubation Time:
Result: Induced cell cycle arrest at M phase in a dose-dependent manner.
体内研究
(In Vivo)

Tubulin inhibitor 47 (6, 12 mg/kg; i.p.; daily for 15 days) 表现出剂量依赖性抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, female BALA/c-nu nude mice (KYSE30 cells)[1]
Dosage: 6, 12 mg/kg
Administration: I.p.; daily for 15 days
Result: Decreased tumor growth in a dose-dependent manner and showed no significant changes in animal weight during treatment.
分子量

316.35

Formula

C20H16N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 47 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 47Tubulin inhibitor47Tubulin inhibitor-47Microtubule/TubulinApoptosisapoptosisM phaseKYSE30 cellsanti-tumortubulin polymerizationInhibitorinhibitorinhibit

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目录号：
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