2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-12

Tubulin polymerization-IN-12 是微管蛋白聚合的抑制剂 (IC50=0.75 μM)。Tubulin polymerization-IN-12 能够阻滞细胞周期在 G2/M 期，对癌细胞显示出细胞毒性。

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Tubulin polymerization-IN-12 Chemical Structure

Tubulin polymerization-IN-12 Chemical Structure

CAS No. : 2377301-45-4

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Tubulin polymerization-IN-12 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
29.94 μM
Compound: 6
Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
[PMID: 32717486]
HeLa IC50
0.75 μM
Compound: 6
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 48 hrs by MTT assay
[PMID: 32717486]
体外研究
(In Vitro)

Tubulin polymerization-IN-12 (compound 6) 对正常人胚胎肾细胞 HEK-293 显示出细胞毒性，IC50 值为 29.94 μM[1]。
Tubulin polymerization-IN-12 (compound 26) 抑制癌细胞的 IC50 分别为 1.02 μM (A549)，0.75 μM (HeLa)，10.91 μM (HCT116)，和 29.94 μM (HEK293)[2]。
Tubulin polymerization-IN-12 (1 μM, 2 μM, 10 μM; 6 h) 抑制 HeLa 细胞中的微管蛋白表达，在 10 μM 时抑制率为 42%[2]。
Tubulin polymerization-IN-12 (0.75 μM-3 μM；24 h) 使 HeLa 细胞的细胞周期停滞在 G2/M 期[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-12 相关抗体:

Immunofluorescence[2]

Cell Line: HeLa cells
Concentration: 1 μM, 2 μM
Incubation Time: 6 hours
Result: Dose-dependently decreased the level of α and β tubulin.

Cell Cycle Analysis[2]

Cell Line: HeLa cells
Concentration: 0.75 μM, 1.5 μM, 3 μM
Incubation Time: 24 hours
Result: Demonstrated 15.03% (0.75 μM), 20.04% (1.50 μM), and 33.47% (3.00 μM) of cell accumulation in G2/M phase.
分子量

465.46

Formula

C23H23N5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-12 相关分类

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Keywords:

Tubulin polymerization-IN-122377301-45-4Microtubule/TubulinInhibitorinhibitorinhibit

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