2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-13

Tubulin polymerization-IN-13 (Compound 4f) 是一种微管蛋白聚集抑制剂 (IC50=0.37 μM) 。Tubulin polymerization-IN-13 表现出对癌细胞的抗增殖活性，可诱导细胞凋亡，具有潜在的抗血管活性。

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Tubulin polymerization-IN-13 Chemical Structure

Tubulin polymerization-IN-13 Chemical Structure

CAS No. : 2426665-56-5

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Tubulin polymerization-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-13 (Compound 4f) is a tubulin polymerization inhibitor (IC50=0.37 μM). Tubulin polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces apoptosis and potential antivascular activity[1].

IC50 & Target

IC50: 0.37 μM (tubulin polymerization)[1]
体外研究
(In Vitro)

Tubulin polymerization-IN-13 (0.005-2.8 nM) treatment inhibits tumor cell proliferation[1].
Tubulin polymerization-IN-13 (8.7-10 μM) is non-toxic in non-tumor cells[1].
Tubulin polymerization-IN-13 (1-50 nM; 24 h) treatment induces cell cycle arrest in G2/M[1].
Tubulin polymerization-IN-13 (10 nM; 24 and 48 h) treatment induces cell apoptosis[1].
Tubulin polymerization-IN-13 (10-100 nM; 24 h) treatment induces alteration of the microtubule network[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-13 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HeLa, HT-29, Daoy, HL-60, SEM, and Jurkat cells
Concentration: 0.005-2.8 nM
Incubation Time:
Result: Showed IC50s of 2.8 nM, 2.1 nM, 0.005 nM, 2.7 nM, 0.31 nM, and 0.28 nM for HeLa, HT-29, Daoy, HL-60, SEM, and Jurkat cells, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: Peripheral blood lymphocytes (PBL)
Concentration: 8.7-10 μM
Incubation Time:
Result: Showed a GI50 of 8.7 μM in quiescent lymphocytes.

Cell Cycle Analysis[1]

Cell Line: HeLa cells
Concentration: 1, 5, 10, and 50 nM
Incubation Time: 24 hours
Result: Induced a G2/M arrest at 10 nM, increased G2/M cells accompanied by a strong reduction of cells in the G1 phase.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 10 nM
Incubation Time: 24 and 48 hours
Result: Induced caspase-9 activation, PARP cleavage, Bcl-2 phosphorylation and Mcl-1 downregulation.

Immunofluorescence[1]

Cell Line: HeLa cells
Concentration: 10, 50, and 100 nM
Incubation Time: 24 hours
Result: Showed the disorganization of microtubules at 10 nM, and much more evident at 50 and 100 nM.
体内研究
(In Vivo)

Tubulin polymerization-IN-13 (intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times) reduces tumor growth in a dose-dependent manner in an orthotopic murine tumor model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old C57BL/6 female mice orthotopically injected into the mammary fat pad with E0771 mammary carcinoma cells[1]
Dosage: 15 or 5 mg/kg
Administration: Intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times
Result: Reduced tumor mass by 45.7% and 16.9% at 15 and 5 mg/kg, respectively.
Showed no sign of toxicity and no decreasement in animal body weight.
分子量

371.38

Formula

C20H21NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-13 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-132426665-56-5Microtubule/TubulinApoptosisanti-proliferative activityinduces apoptosisantivascular activityHeLaHT-29DaoyHL-60SEMJurkatInhibitorinhibitorinhibit

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