2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-16

Tubulin aggregation-IN-16 (compound 5g) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞最有效，IC50 值为 0.084-0.221 μM。Tubulin 聚合-IN-16 可有效破坏微管/微管蛋白动力学，在 SGC-7901 细胞中诱导 G2/M 期细胞周期停滞。

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Tubulin polymerization-IN-16 Chemical Structure

Tubulin polymerization-IN-16 Chemical Structure

CAS No. : 2296731-38-7

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Tubulin polymerization-IN-16 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.133 μM
Compound: 5g
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31740055]
HeLa IC50
0.221 μM
Compound: 5g
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31740055]
SGC-7901 IC50
0.084 μM
Compound: 5g
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 31740055]
分子量

465.50

Formula

C24H27N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-16 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-162296731-38-7Microtubule/TubulintubulinpolymerizationcancermicrotubuleG2/M phaseInhibitorinhibitorinhibit

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