2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-8

Tubulin aggregation-IN-8 (compound IIc) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-8 浓度依赖性地导致 HCT116 肿瘤细胞 G2/M 期细胞周期停滞，并显示显着抑制微管蛋白聚合，IC50 值为 12.7 μM。Tubulin aggregation-IN-8 具有研究癌症疾病的潜力。

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Tubulin polymerization-IN-8 Chemical Structure

Tubulin polymerization-IN-8 Chemical Structure

CAS No. : 2768485-08-9

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Tubulin polymerization-IN-8 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC50 value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases[ 1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
1.46 μM
Compound: IIc
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HEK293 IC50
> 100 μM
Compound: IIc
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HeLa IC50
9.02 μM
Compound: IIc
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HepG2 IC50
3.65 μM
Compound: IIc
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
HT-29 IC50
0.62 μM
Compound: IIc
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35398303]
分子量

428.50

Formula

C21H24N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-8 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-82768485-08-9Microtubule/Tubulintubulin polymerizationcell cycle arrestG2/McancerInhibitorinhibitorinhibit

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