UK-1

目录号: HY-129558: FAQs
Data Sheet 产品使用指南技术支持

UK-1 是链霉菌 517-02 的细胞毒性代谢产物，具有广泛的抗肿瘤活性。UK-1 还可抑制HCV复制。

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UK-1 Chemical Structure

CAS No. : 151271-53-3

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规格	价格	是否有货
1 mg	￥5897	3 - 4 周
5 mg		询价
10 mg		询价

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参考文献

生物活性

UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities^[1]. UK-1 also inhibits HCV replication^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs in presence of CuCl2 Cytotoxicity against human A549 cells after 72 hrs in presence of CuCl2	[PMID: 18037301]
A549	IC₅₀	1 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs Cytotoxicity against human A549 cells after 72 hrs	[PMID: 18037301]
A549	IC₅₀	17 μM Compound: UK-1	Cytotoxicity against human A549 cells after 24 hrs Cytotoxicity against human A549 cells after 24 hrs	[PMID: 18037301]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay	[PMID: 23123017]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells by Alamar blue assay Cytotoxicity against human A549 cells by Alamar blue assay	[PMID: 18037301]
A549	IC₅₀	4.5 μM Compound: UK-1	Cytotoxicity against human A549 cells after 24 hrs in presence of CuCl2 Cytotoxicity against human A549 cells after 24 hrs in presence of CuCl2	[PMID: 18037301]
Huh-7	EC₅₀	0.77 μM Compound: UK-1	Antiviral activity against HCV infected in human Huh7ET cells assessed as inhibition of viral replication by luciferase reporter gene assay/RNA blot hybridization analysis Antiviral activity against HCV infected in human Huh7ET cells assessed as inhibition of viral replication by luciferase reporter gene assay/RNA blot hybridization analysis	[PMID: 24360997]
Huh-7	CC₅₀	17 μM Compound: UK-1	Cytotoxicity against human Huh7ET cells by neutral red assay Cytotoxicity against human Huh7ET cells by neutral red assay	[PMID: 24360997]
MCF7	IC₅₀	1.2 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs in presence of CuCl2 Cytotoxicity against human MCF7 cells after 72 hrs in presence of CuCl2	[PMID: 18037301]
MCF7	IC₅₀	1.4 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]
MCF7	IC₅₀	1.4 μM Compound: UK-1	Cytotoxicity against human MCF7 cells by Alamar blue assay Cytotoxicity against human MCF7 cells by Alamar blue assay	[PMID: 18037301]
MCF7	IC₅₀	1.7 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs	[PMID: 18037301]
MCF7	IC₅₀	31 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 18037301]
MCF7	IC₅₀	4.6 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 24 hrs in presence of CuCl2 Cytotoxicity against human MCF7 cells after 24 hrs in presence of CuCl2	[PMID: 18037301]

分子量

386.36

Formula

C₂₂H₁₄N₂O₅

CAS 号

151271-53-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1993 Jul;46(7):1089-94. [Content Brief]

[2]. Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12. [Content Brief]

UK-1 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK-1151271-53-3UK1UK 1HCVHepatitis C virusInhibitorinhibitorinhibit

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UK-1

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