2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. UMB68 sodium

UMB68 sodium 是一种选择性的 GHB 受体配体。UMB68 sodium 在大鼠脑皮膜中置换 [3H]NCS-382，IC50 值为 38 nM。UMB68 sodium 对 GABAB 受体没有明显的亲和力，无法代谢为 GABA 活性化合物。

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UMB68 sodium Chemical Structure

UMB68 sodium Chemical Structure

CAS No. : 581099-89-0

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UMB68 sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].

IC50 & Target

GHB receptor[1]
体外研究
(In Vitro)

UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].
UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UMB68 sodium 相关抗体:
体内研究
(In Vivo)

UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1]
Dosage: 320, 660, 1000, 1778 mg/kg
Administration: I.p. injection
Result: Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
分子量

154.14

Formula

C6H11NaO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UMB68 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

UMB68581099-89-0UMB 68UMB-68GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGHBNCS-382cerebrocorticalmembranesGABInhibitorinhibitorinhibit

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