2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. UNC-2170 maleate

UNC-2170 maleate 是 UNC-2170 (HY-115531) 的马来酸盐形式。UNC-2170 maleate 是甲基赖氨酸结合蛋白 53BP1 的选择性抑制剂，IC50 为 29 µM，Kd 为 22 µM。UNC-2170 maleate 与其他九种甲基赖氨酸 (Kme) 读取蛋白相比，对 53BP1 的选择性至少高出 17 倍。53BP1 是一种 Kme 结合蛋白，在 DNA 损伤修复 (DDR) 通路中起着核心作用，并被募集到双链断裂 (DSB) 的位点。

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UNC-2170 maleate Chemical Structure

UNC-2170 maleate Chemical Structure

CAS No. : 2173992-60-2

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UNC-2170 maleate 的其他形式现货产品:

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UNC-2170 maleate 相关抗体

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生物活性

UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].

分子量

429.31

Formula

C18H25BrN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC-2170 maleate 相关分类

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Keywords:

UNC-21702173992-60-2UNC2170UNC 2170DNA/RNA SynthesisDDRDSBDNA damage repairInhibitorinhibitorinhibit

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UNC-2170 maleate
目录号：
HY-118897
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