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  4. UNC8732

UNC8732 是一种促蛋白质降解 (TPD) 剂。UNC8732 通过胺氧化酶催化产生醛类代谢物，该物质通过与泛素 E3 连接酶 FBXO22 的 C326 结合，从而招募 SCFFBXO22 Cullin 复合物。招募到的 FBXO22，则进一步诱导组蛋白甲基转移酶和致癌基因 NSD2 的降解。

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UNC8732 Chemical Structure

UNC8732 Chemical Structure

CAS No. : 2929304-05-0

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UNC8732 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC8732 is a targeted protein degradation (TPD) agent. It generates aldehyde metabolites through amine oxidase catalysis, which bind to C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. The recruited FBXO22 further induces degradation of histone methyltransferases and the oncogene NSD2[1].

分子量

609.71

Formula

C35H39N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC8732 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC87322929304-05-0UNC 8732UNC-8732OthersInhibitorinhibitorinhibit

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目录号：
HY-161796
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