2. Neuronal Signaling
  3. Dopamine Transporter Serotonin Transporter
  4. UWA-101 hydrochloride

UWA-101 hydrochloride 是一种选择性、无细胞毒性的 DAT/SERT 抑制剂，其抑制 DAT 和 SERT 的EC50 值分别为 3.6 µM 和 2.3 µM。UWA-101 hydrochloride 可减轻多巴胺能活性分子 (如 L-DOPA) 的副作用 (如运动障碍)，并不具有精神活性。UWA-101 hydrochloride 可用于神经退行性疾病 (如帕金森病) 的研究。

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UWA-101 hydrochloride Chemical Structure

UWA-101 hydrochloride Chemical Structure

CAS No. : 1431520-52-3

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UWA-101 hydrochloride 相关抗体

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生物活性

UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2].

体内研究
(In Vivo)

UWA-101 hydrochloride (3 mg/kg; i.p.; single) 减少 L-DOPA 在帕金森病大鼠模型中产生的运动障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g; Parkinson's disease model)[1].
Dosage: 3 mg/kg
Administration: Intraperitoneal injection
Result: Reduced L-DOPA-induced vertical activity by 60%.
分子量

255.74

Formula

C13H18ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UWA-101 hydrochloride 相关分类

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Keywords:

UWA-1011431520-52-3UWA101UWA 101Dopamine TransporterSerotonin TransporterDATSLC6A35-HTTSERTSLC6A4Parkinson'sneurodegenerative diseases5-HTdopamineInhibitorinhibitorinhibit

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