Vaniprevir (Synonyms: MK-7009)

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Data Sheet SDS COA 产品使用指南技术支持

Vaniprevir (MK-7009) 是非共价的 HCV NS3/4A 蛋白酶抑制剂。

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Vaniprevir Chemical Structure

CAS No. : 923590-37-8

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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

•Personalized Medicine Universe. 2019 May.

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生物活性
纯度 & 产品资料
参考文献

生物活性

Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.27 nM Compound: MK-7009	Antiviral activity against HCV1b harboring Q80Q polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay Antiviral activity against HCV1b harboring Q80Q polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay	[PMID: 20855726]
Huh-7	EC₅₀	0.41 nM Compound: MK-7009	Antiviral activity against HCV1b harboring Q80K polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay Antiviral activity against HCV1b harboring Q80K polymorphism in NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay	[PMID: 20855726]
Huh-7	EC₅₀	0.7 nM Compound: MK-7009	Antiviral activity against HCV1b Con1 harboring NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay Antiviral activity against HCV1b Con1 harboring NS3 protease gene infected in human Huh7/Lunet cells assessed as inhibition of viral replication after 3 days by luciferase based transient-transfection assay	[PMID: 20855726]
Huh-7	IC₅₀	19 nM Compound: 35b, vaniprevir, MK-7009	Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 50% normal human serum Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 50% normal human serum	[PMID: 20163176]
Huh-7	IC₅₀	19 nM Compound: 1, MK-7009	Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS	[PMID: 24900473]
Huh-7	IC₅₀	3 nM Compound: 35b, vaniprevir, MK-7009	Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum Antiviral activity against HCV Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum	[PMID: 20163176]
Huh-7	EC₅₀	5 nM Compound: MK-7009	Antiviral activity against HCV 1B infected in human Huh7 cells by firefly luciferase reporter gene assay Antiviral activity against HCV 1B infected in human Huh7 cells by firefly luciferase reporter gene assay	[PMID: 20541424]
Huh-7	IC₅₀	9 nM Compound: 35b, vaniprevir, MK-7009	Antiviral activity against HCV JFH-1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum Antiviral activity against HCV JFH-1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs by replicon assay in presence of 10% fetal bovine serum	[PMID: 20163176]

Clinical Trial

分子量

757.94

Formula

C₃₈H₅₅N₅O₉S

CAS 号

923590-37-8

性状

固体

颜色

White to off-white

中文名称

伐尼瑞韦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

纯度 & 产品资料

纯度: 99.60%

选择批次：

Data Sheet (531 KB) SDS (252 KB)

COA (201 KB) HNMR (231 KB) LCMS (320 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Liverton, Nigel J.; Carroll, Steven S.; Di Muzio, Jillian;.MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrobial Agents and Chemotherapy (2009), Volume Date 2010, 54(1), 305-311. [Content Brief]

[2]. Kong J, Chen CY, Balsells-Padros J, Cao Y, Dunn RF, Dolman SJ, Janey J, Li H, Zacuto MJ.Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis strategy.J Org Chem. 2012 Apr 20;77(8):3820-8. Epub 2012 Apr 10. [Content Brief]

[3]. Manns MP, Gane E, Rodriguez-Torres M, Stoehr A, Yeh CT, Marcellin P, Wiedmann RT, Hwang PM, Caro L, Barnard RJ, Lee AW; for the MK-7009 Protocol 007 Study Group.Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-na?ve patients with c [Content Brief]

[4]. Song ZJ, Tellers DM, Journet M, Kuethe JT, Lieberman D, Humphrey G, Zhang F, Peng Z, Waters MS, Zewge D, Nolting A, Zhao D, Reamer RA, Dormer PG, Belyk KM, Davies IW, Devine PN, Tschaen DM.Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-m [Content Brief]

[5]. McCauley JA, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, Gilbert KF, Bush KJ, Holloway MK, Swestock J, Wan BL, Carroll SS, DiMuzio JM, Graham DJ, Ludmerer SW, Mao SS, Stahlhut MW, Fandozzi CM, Trainor N, Olsen DB, Vacca JP, Liverton NJ.Discove [Content Brief]

Vaniprevir 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vaniprevir923590-37-8MK-7009伐尼瑞韦MK7009MK 7009HCVHCV ProteaseHepatitis C virusInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Vaniprevir (Synonyms: MK-7009)

Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

Vaniprevir 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Vaniprevir 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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Vaniprevir (Synonyms: MK-7009)

Customer Review

Vaniprevir 相关抗体

MCE 顾客使用本产品发表的 1 篇科研文献

Vaniprevir 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Vaniprevir 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

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