2. Membrane Transporter/Ion Channel
  3. VDAC
  4. VBIT-3

VBIT-3 是一种电压依赖性阴离子通道 (VDAC) 低聚物抑制剂，Kd 为 31.3 μM。 VBIT-3，作为细胞凋亡 (apoptosis) 抑制剂，用于研究与细胞凋亡相关的疾病，例如神经退行性疾病和心血管疾病等。

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VBIT-3 Chemical Structure

VBIT-3 Chemical Structure

CAS No. : 2088463-66-3

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VBIT-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

IC50 & Target

Kd: 31.3 μM (VDAC1)[1]
Apoptosis[1]
体外研究
(In Vitro)

VBIT-3 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction[1].
VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VBIT-3 相关抗体:

Apoptosis Analysis[1]

Cell Line: HEK-293 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time:
Result: Inhibited apoptosis with an IC50 of 7.5±0.27μM.
分子量

453.84

Formula

C21H19ClF3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VBIT-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VBIT-32088463-66-3VBIT3VBIT 3VDACVoltage-dependent anion channelVDAC1oligomerizationneurodegenerativecardiovascularInhibitorinhibitorinhibit

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目录号：
HY-135571
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