2. Protein Tyrosine Kinase/RTK Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. VEGFR Microtubule/Tubulin Apoptosis
  4. VEGFR-2-IN-22

VEGFR-2-IN-22 (Compound 25) 是一种 VEGFR-2 和 β-tubulin 聚合抑制剂，对 VEGFR-2 的IC50 为 19.82 nM。VEGFR-2-IN-22 诱导细胞凋亡 (apoptosis)。

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VEGFR-2-IN-22 Chemical Structure

VEGFR-2-IN-22 Chemical Structure

CAS No. : 2447587-73-5

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VEGFR-2-IN-22 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].

IC50 & Target

VEGFR2

19.82 nM (IC50)

体外研究
(In Vitro)

VEGFR-2-IN-22 (Compound 25) shows inhibition with an IC50 of 0.24 ± 0.06 µM against HepG2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-22 相关抗体:
分子量

542.94

Formula

C26H24ClFN4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-222447587-73-5VEGFRMicrotubule/TubulinApoptosisVascular endothelial growth factor receptorHepG2anti-cancertubulinantitumorBAXBCL-2p53Inhibitorinhibitorinhibit

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