2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis MDM-2/p53
  4. VEGFR-2-IN-23

VEGFR-2-IN-23 (compound 11b) 是一种有效的选择性 VEGFR-2 抑制剂，IC50 值为 0.34 nM。VEGFR-2-IN-23 显示出抗肿瘤活性。VEGFR-2-IN-23 诱导细胞凋亡 (apoptosis) 和 MCF-7 细胞停滞在 G1 期。

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VEGFR-2-IN-23 Chemical Structure

VEGFR-2-IN-23 Chemical Structure

CAS No. : 2411174-53-1

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VEGFR-2-IN-23 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

IC50 & Target[1]

VEGFR-2

0.19 nM (IC50)

体外研究
(In Vitro)

VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC50s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-23 相关抗体:
体内研究
(In Vivo)

VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

381.39

Formula

C22H15N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-232411174-53-1VEGFRApoptosisMDM-2/p53Vascular endothelial growth factor receptorMCF-7 cellsanticancerMCF-7 p53 knockdown cellsp53Bcl2 proteinapoptosisG1 phaseInhibitorinhibitorinhibit

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目录号：
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