Vinorelbine (Synonyms: 长春瑞滨; KW-2307 base)

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Vinorelbine(KW-2307 base)是抗有丝分裂剂，能抑制Hela细胞增殖，IC50为1.25 nM。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Vinorelbine ditartrate。

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Vinorelbine Chemical Structure

CAS No. : 71486-22-1

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Vinorelbine 的其他形式现货产品:

Vinorelbine ditartrate

Other Forms of Vinorelbine:

Vinorelbine ditartrate In-stock

MCE 顾客使用本产品发表的 13 篇科研文献

•Biochem Biophys Res Commun. 2020 May 21;526(1):154-157. [Abstract]

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参考文献

生物活性	Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.
体外研究 (In Vitro)	Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC₅₀) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase^[1]. Vinorelbine time-dependently induces the p53 and p21^WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Vinorelbine 相关抗体:
体内研究 (In Vivo)	After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs^[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m²^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	778.93
Formula	C₄₅H₅₄N₄O₈
CAS 号	71486-22-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (539 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32. [Content Brief] [2]. Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73. [Content Brief] [3]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. [Content Brief] [4]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8. [Content Brief]

Animal Administration ^[4]	As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks at the owner's expense. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32. [Content Brief] [2]. Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73. [Content Brief] [3]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. [Content Brief] [4]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8. [Content Brief]

Animal Administration
^[4]

As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks at the owner's expense.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32. [Content Brief]

[2]. Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73. [Content Brief]

[3]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. [Content Brief]

[4]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8. [Content Brief]

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Vinorelbine71486-22-1KW-2307 baseMicrotubule/TubulinAutophagyInhibitorinhibitorinhibit

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Vinorelbine (Synonyms: 长春瑞滨; KW-2307 base)

Other Forms of Vinorelbine:

MCE 顾客使用本产品发表的 13 篇科研文献

Vinorelbine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Vinorelbine 相关分类

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Vinorelbine (Synonyms: 长春瑞滨; KW-2307 base)

Other Forms of Vinorelbine:

Vinorelbine 相关抗体

MCE 顾客使用本产品发表的 13 篇科研文献

Vinorelbine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Vinorelbine 相关抗体:

Vinorelbine 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

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