2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. VU0546110

VU0546110 是精子特异性钾通道 SLO3 的选择性抑制剂，HEK293 细胞中 SLO3 和 SLO1 的 IC50 分别为 1.287 μM 和 59.80 μM。VU0546110 阻断人类精子中的异源 SLO3 电流和内源性 K+ 电流。VU0546110 阻止精子超极化、诱导的顶体反应和过度激活的运动。VU0546110 具有避孕潜力。

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VU0546110 Chemical Structure

VU0546110 Chemical Structure

CAS No. : 1421523-00-3

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VU0546110 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential[1].

IC50 & Target

1.287 μM (SLO3), 59.80 μM (SLO1)[1]
体外研究
(In Vitro)

VU0546110 (10 μM) 在细胞内游离 Ca2+ 浓度为 0-50 µM 时阻断人类精子中的 K+ 电流[1]。
VU0546110 (2.5 μM) 抑制人类精子在 pH 8.0 时具有的超极化膜电位[1]。
VU0546110 (2.5-10 μM) 抑制人类精子中过度激活的运动和 Ca2+ 促进剂 A23187 (HY-N6687) 或黄体酮 (HY-N0437) 诱导的顶体反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VU0546110 相关抗体:
分子量

461.64

Formula

C24H31NO4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU0546110 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU05461101421523-00-3VU 0546110VU-0546110Potassium ChannelKcsASpermHyperpolarizationFertilizationHEK293 CellsAcrosome reactionInhibitorinhibitorinhibit

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产品名称：
VU0546110
目录号：
HY-164911
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