2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. WB518

WB518 是一种有效的 STAT3 抑制剂。 WB518 有效抑制 STAT3 活性和角蛋白 17 表达。WB518 通过抑制 STAT3 磷酸化和角蛋白 17，可有效缓解 imiquimod (HY-B0180) 和 TPA (HY-18739) 诱导的动物银屑病。

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WB518 Chemical Structure

WB518 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

WB518 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17[1].

IC50 & Target

STAT3

 

p-STAT3

 

体外研究
(In Vitro)

WB518 (5-25 μM) 通过抑制 STAT3 Tyr705 (Y705) 的磷酸化，显着降低 HaCaT 细胞中角蛋白 17 (K17) 的 mRNA 和蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WB518 相关抗体:

Western Blot Analysis[1]

Cell Line: HaCaT cells
Concentration: 0, 5, 25 μM
Incubation Time: 12 h
Result: Decreased K17 mRNA levels following stimulation with IL-22 (100 ng/ml) or IL-17A (300 U/ml) compared to untreated cells. Concentration-dependently down-regulated K17 protein expression by inhibiting STAT3 activation, without affecting the ERK or STAT1 pathway.
体内研究
(In Vivo)

WB518 (每个部位 17.5 μg 和 35 μg，外用，每日，持续 5 天)可改善 TPA (HY-18739) 诱导的银屑病样皮肤炎症，显著改善小鼠银屑病模型的表型特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (6–8 weeks old)[1]
Dosage: 17.5 μg and 35 μg per site
Administration: External application, daily, for 5 days
Result: WB518 (35 μg) exhibited significantly reduced epidermal hyperplasia and dermal infiltration of inflammatory cells compared to mice treated with TPA alone.
分子量

518.34

Formula

C20H16BrN5O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WB518 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WB518WB 518WB-518STATPsoriasisanti-psoriasisHaCaT cellsepidermal hyperplasiaKeratin 17Inhibitorinhibitorinhibit

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目录号：
HY-163176
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