2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. YM928

YM928 是具有口服活性且非竞争性的 α-氨基-3-羟基-5-甲基-4-异噁唑丙酸 (AMPA) receptor 拮抗剂。YM928 抑制初级大鼠海马培养物中由 AMPA receptor 介导的毒性，其 IC50值为 2 μM. 。YM928 阻断 AMPA 诱导的细胞内钙通量，其 IC50值为 3 μM，并拮抗 AMPA 诱导的内向电流，其 IC50 值为 1 μM。YM928 有望用于神经系统疾病的研究中。

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YM928 Chemical Structure

YM928 Chemical Structure

CAS No. : 190842-36-5

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YM928 相关抗体

Top Publications Citing Use of Products

查看 iGluR 亚型特异性产品:

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Neuron IC50
2 μM
Compound: 16i, YM928
Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay
Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay
[PMID: 25792143]
分子量

303.77

Formula

C14H10ClN3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YM928 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM928190842-36-5YM 928YM-928iGluRIonotropic glutamate receptorsorally activeAMPArat hippocampalcalcium influxneurological disordersInhibitorinhibitorinhibit

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