2. Anti-infection
  3. Virus Protease Flavivirus
  4. ZIKV-IN-1

ZIKV-IN-1 是一种有效的 zika virus 抑制剂，EC50 为 2.8 μM，EC90 为 6.8 μM。ZIKV-IN-1 显示出抗 ZIKV 活性，且具有低细胞毒性。ZIKV-IN-1 对 ZIKV RdRp 结构域具有很强的亲和力。

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ZIKV-IN-1 Chemical Structure

ZIKV-IN-1 Chemical Structure

CAS No. : 2762166-06-1

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ZIKV-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain[1]. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

EC50: 2.8 µM (ZIKV)[1]
体外研究
(In Vitro)

ZIKV-IN-1 (compound 38) (0-80 µM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells[1].
ZIKV-IN-1 (5, 10, 25 µM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein[1].
ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 µM; 0-250 s) shows strong affinity to ZIKV RdRp domain (Kd=1.87 µM) in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZIKV-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 0-50 µM
Incubation Time:
Result: Showed anti-ZIKV activity with an EC50 of 2.8 µM, EC90 of 6.8 µM, and CC50 of >50 µM.

Western Blot Analysis[1]

Cell Line: A549, Vero cells
Concentration: 5, 10, 25 µM
Incubation Time: 48 h
Result: Decreased the expression of ZIKV E and cleaved caspase 3 protein.

Cell Cytotoxicity Assay[1]

Cell Line: Vero, SNB19, Huh7, A549 cells
Concentration: 0-80 µM
Incubation Time:
Result: Showed low cytotoxicity with CC50s of 46.8, 49.4, 43.8, 54.1 µM for ZG01 strain of Vero, SNB19, Huh7, A549 cells, and CC50s of 470.5, 485.2, 512.8, 160.8 µM for MR766 strain of Vero, SNB19, Huh7, A549 cells, respectively.
分子量

478.29

Formula

C21H18BrF2N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZIKV-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZIKV-IN-12762166-06-1Virus ProteaseFlaviviruslow cytotoxicityA549 cellsanti-ZIKVcleaved caspase 3 ZIKV RdRp dominZIKV E proteinInhibitorinhibitorinhibit

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