2. Epigenetics Anti-infection
  3. DNA Methyltransferase Virus Protease Flavivirus
  4. ZIKV-IN-3

ZIKV-IN-3 (compound 5a) 是一种穿心莲内酯衍生物, 是有效的 ZIKV NS5 甲基转移酶 (MTase) 抑制剂，其 IC50 值为 18.34 μM。ZIKV-IN-3 抑制 ZIKV 的复制和感染。ZIKV-IN-3 可用于寨卡病毒 (ZIKV) 的研究。

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ZIKV-IN-3 Chemical Structure

ZIKV-IN-3 Chemical Structure

CAS No. : 947699-46-9

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ZIKV-IN-3 相关抗体

Top Publications Citing Use of Products

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DNA Methyltransferase DNMT1 DNMT3 MGMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)[1].

IC50 & Target

IC50: 18.34 μM (MTase)[1]
体外研究
(In Vitro)

ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC50 value of 0.76 μM and has anti-ZIKV effect with EC50 values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC50 value of 0.38 μM and inhibits ZIKV replication and infection[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells[1]. Vero, Huh7 and A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZIKV-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: Vero, Huh7 and A549 cells
Concentration: 0.08, 0.4, 2, 10, and 50 μM
Incubation Time: 96 hours
Result: Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC50>200 μM to all three cell lines.

Western Blot Analysis[1]

Cell Line: Vero cells
Concentration: 0.08, 0.4, 2, 10, and 50 μM
Incubation Time: 48 hours
Result: Inhibited the expression of ZIKV E protein in a dose-dependent manner.
分子量

587.75

Formula

C39H41NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZIKV-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZIKV-IN-3947699-46-9DNA MethyltransferaseVirus ProteaseFlavivirusDNMTsDNA MTasesZika virusandrographolide derivativesVero cellsHuh7 cellsA549 cellsreplicationinfectionInhibitorinhibitorinhibit

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目录号：
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