Zinc Protoporphyrin-d₂,¹⁵N₂  (Synonyms: 锌原卟啉-d₂; Zn(II)-protoporphyrin IX-d2,15N2; ZnPP-d2,15N2; Zinc Protoporphyrin-9-d2,15N2)

Zinc Protoporphyrin-d₂,¹⁵N₂ is ¹⁵N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂^[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration^[2]. Zinc Protoporphyrin has anti-cancer activity^[3].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Zinc Protoporphyrin (Zn (II)-protoporphyrin IX；5 μM；72 hours) 导致晚期凋亡和坏死细胞的比例从对照组的 10.9% 增加到 72 小时后的 30.4%^[4]。
Zinc Protoporphyrin (1.25-40 μM；48 或 72 小时) 对肿瘤细胞产生抑囊/细胞毒性作用^[4]。
Zinc Protoporphyrin (2.5、5 μM；48 或 72 小时) 导致细胞周期 G1 期细胞的剂量和时间依赖性减少^[4]。
Zinc Protoporphyrin (1.25-40 μM；48 小时) 导致裂解 (活性) caspase-3 的积累^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

原卟啉锌 (12.5、25、50 mg/kg 腹腔注射；12.5、50 mg/kg 口服；从第 7 天到第 19 天) 发挥剂量依赖性抗肿瘤作用，表现为延缓肿瘤生长^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

630.02

C₃₄H₃₀D₂N₂¹⁵N₂O₄Zn

15442-64-5

锌原卟啉-d₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4).  [Content Brief]

  [3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.  [Content Brief]

  [4]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.  [Content Brief]