2. PI3K/Akt/mTOR
  3. PIN1
  4. ZL-Pin13

ZL-Pin13 是一种高效细胞活性共价抑制剂，靶向 Pin1，IC50 为 67 nM。ZL-Pin13 有效抑制 MDA-MB-231 细胞的增殖并下调 Pin1 底物。

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ZL-Pin13 Chemical Structure

ZL-Pin13 Chemical Structure

CAS No. : 2883498-73-3

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ZL-Pin13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 IC50
2.8 μM
Compound: ZL-Pin13
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 35089030]
MDA-MB-468 IC50
1.9 μM
Compound: ZL-Pin13
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 35089030]
分子量

454.97

Formula

C24H23ClN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZL-Pin13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZL-Pin132883498-73-3PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1MDA-MB-231 cellscovalentPin1proliferationInhibitorinhibitorinhibit

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