2. Apoptosis
  3. Apoptosis
  4. ZZW-115

ZZW-115 是一种有效的 NUPR1 抑制剂，Kd 为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 ZZW-115 hydrochloride 通常具有更好的水溶性和稳定性。

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ZZW-115 Chemical Structure

ZZW-115 Chemical Structure

CAS No. : 801991-87-7

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ZZW-115 的其他形式现货产品:

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ZZW-115 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZZW-115 is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity[1][2].

体外研究
(In Vitro)

ZZW-115 (0.1-33 μM; 72 hours) is efficient in killing cancer cells, with an IC50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14)[1].
ZZW-115 (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells)[1].
ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction[1].
LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZZW-115 相关抗体:

Cell Viability Assay[1]

Cell Line: ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells
Concentration: 0.1- 33 μM
Incubation Time: 72 hours
Result: Was efficient in killing cancer cells, with an IC50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).

Cell Proliferation Assay[1]

Cell Line: U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells
Concentration: 0-100 μM
Incubation Time: 24 or 72 hours
Result: Was efficient to kill these tumor cells with an IC50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
体内研究
(In Vivo)

ZZW-115 (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors[1].
ZZW-115 (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells[1]
Dosage: 5, 2.5, 1.0, or 0.5 mg/kg
Administration: Injection, daily for 30 days
Result: When the mice were injected with 5 mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.
分子量

464.59

Formula

C24H31F3N4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZZW-115 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZZW-115801991-87-7ZZW115ZZW 115ApoptosispancreaticcancercellgrowthnecroptosisPDACATPROSInhibitorinhibitorinhibit

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