α-Conotoxin GID 

α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC₅₀s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species^[1][2][3].

IC50: 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2)^[1]

2186.39

C₈₄H₁₃₂N₃₀O₃₁S₄

547741-78-6

Ile-Arg-Asp-{Gla}-Cys-Cys-Ser-Asn-Pro-Ala-Cys-Arg-Val-Asn-Asn-{Hyp}-His-Val-Cys (Disulfide bridge：Cys5-Cys11, Cys6-Cys19)

IRD-{Gla}-CCSNPACRVNN-{Hyp}-HVC (Disulfide bridge：Cys5-Cys11, Cys6-Cys19)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Armishaw CJ. Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads. Toxins (Basel). 2010 Jun;2(6):1471-99.  [Content Brief]

  [2]. Millard EL, et al. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. 2009 Feb 20;284(8):4944-51.  [Content Brief]

  [3]. Nicke A, et al. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem. 2003 Jan 31;278(5):3137-44.  [Content Brief]