2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. αO-Conotoxin GeXIVA

αO-Conotoxin GeXIVA 是一种有效的 α9α10 nAChR 拮抗剂，对大鼠 α9α10 的 IC50 为 12 nM。αO-Conotoxin GeXIVA 在疼痛动物模型中表现出缓解疼痛作用。

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αO-Conotoxin GeXIVA Chemical Structure

αO-Conotoxin GeXIVA Chemical Structure

CAS No. : 2010167-25-4

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αO-Conotoxin GeXIVA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].

IC50 & Target

IC50: 12 nM (rat α9α10), 52 nM (human α9α10), 520 nM (mouse α1β1δε), 660 nM (rat α7), 940 nM (rat α3β2), 1380 nM (rat α6/α3β4), 1610 nM (rat α2β2), 6930 nM (rat α3β4)[1]
分子量

3452.89

Formula

C139H227N55O41S4
CAS 号
Sequence

Thr-Cys-Arg-Ser-Ser-Gly-Arg-Tyr-Cys-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Cys-Arg-Arg-Ile-Thr-Asp-Ala-Cys-Val (Disulfide bridge:Cys2-Cys9;Cys20-Cys27)
Sequence Shortening

TCRSSGRYCRSPYDRRRRYCRRITDACV (Disulfide bridge:Cys2-Cys9;Cys20-Cys27)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

αO-Conotoxin GeXIVA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

αO-Conotoxin GeXIVA2010167-25-4nAChRNicotinic acetylcholine receptorsConus generalisanalgesicpainInhibitorinhibitorinhibit

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