2. Neuronal Signaling
  3. Amyloid-β
  4. γ-Secretase modulator 13

γ-Secretase modulator 13 (compound 4) 是一种 γ-分泌酶调节剂 (GSMs)，可以抑制聚集的淀粉样蛋白 β 肽Aβ42 的产生，其 IC50 值为163 nM。可以用于阿尔茨海默病的研究。

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γ-Secretase modulator 13 Chemical Structure

γ-Secretase modulator 13 Chemical Structure

CAS No. : 1353570-40-7

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γ-Secretase modulator 13 相关抗体

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  • 生物活性

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生物活性

γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SH-SY5Y IC50
163 nM
Compound: 6
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
[PMID: 27426299]
分子量

422.52

Formula

C22H23FN6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

γ-Secretase modulator 13 相关分类

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Keywords:

γ-Secretase modulator 131353570-40-7Amyloid-ββ-amyloid peptideAβAbetagamma-secretase modulatorGSMsaggregated amyloid β-peptideAβ42Alzheimer's diseaseInhibitorinhibitorinhibit

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