2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. α-Conotoxin BuIA

α-Conotoxin BuIA 是一种麻痹肽神经毒素和竞争性 nAChR 拮抗剂，IC50 为 0.258 nM (α6/α3β2)，1.54 nM (α6/α3β4)、5.72 nM (α3β2)。α-Conotoxin BuIA 可用于区分分别含有 β2 和 β4 亚基的 nAChR。α-Conotoxin BuIA 可区分 αxβ2 nAChR，效力顺序为 α6>α3>α2>α4。

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Custom Peptide Synthesis

α-Conotoxin BuIA Chemical Structure

α-Conotoxin BuIA Chemical Structure

CAS No. : 846539-62-6

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α-Conotoxin BuIA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4[1].

IC50 & Target

IC50: 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2)[1]
分子量

1311.57

Formula

C54H82N14O16S4
CAS 号
Sequence

Gly-Cys-Cys-Ser-Thr-Pro-Pro-Cys-Ala-Val-Leu-Tyr-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys13)
Sequence Shortening

GCCSTPPCAVLYC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Conotoxin BuIA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Conotoxin BuIA846539-62-6nAChRNicotinic acetylcholine receptorsparalytic peptide neurotoxincompetitiveInhibitorinhibitorinhibit

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α-Conotoxin BuIA
目录号：
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